| College: |
University of California, Los Angeles, BS |
Medical School: |
University of California, San Francisco, MD |
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Internal Medicine Residency: |
University of California, San Francisco
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Postgraduate Fellowship:
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University of California, San Francisco
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Interests
Research: Kidney, bone, nutrition, acid-base, potassium and health, blood pressure, evolutionary biology, evolutionary medicine, endothelium; vitamin D and health, history of medicine, systems biology, polyphenols, oxidative stress
Other: Peer-reviewer of many manuscripts; practicing writing with clarity and grace; mentoring young clinical investigators; facilitating quality clinical research; reading and writing poetry; bibliophile; writing encyclopedia articles in biology and health sciences.
Anthony Sebastian’s Pofile on Nature Network: http://network.nature.com/people/anthonysebastian/profile
In the News
Distinguished Clinical Research Lecture
ACADEMIC SENATE'S FIFTH ANNUAL DISTINGUISHED CLINICAL RESEARCH LECTURE Awarded to R. Curtis Morris, Jr. MD and Anthony Sebastian, MD as Co-Recipients ...
http://senate.ucsf.edu/0-awards/DCRL-pastrecipients.html
UCSF today article: "Scientists Honored for Advances in Research and Patient Care"
http://pub.ucsf.edu/today/spotlight.php?news_id=200212105
UCSF News Release: "Potassium-rich foods can help offset high salt diet contribution to osteoporosis, UCSF study finds"
http://pub.ucsf.edu/newsservices/releases/200307221
Science Daily: "High Animal Protein Intake May Increase Risk Of Bone Loss And Fractures In Elderly Women, UCSF Study Finds"
http://www.sciencedaily.com/releases/2000/12/001227082125.htm
U.S. News & World Report: Sebastian et al. Where's the beef? November 27, 2000
USDA Nutrition and Your Health:Dietary Guidelines for Americans
http://www.health.gov/dietaryguideline...D7_Fluid.htm
Articles To Help You Achieve Optimum Health, Pinnacle Enterprises
The pH Nutrition Guide to Acid / Alkaline Balance
Purify Your Mind
Calcium Controversy
http://www.purifymind.com/CalciumControversy.htm
The Center for Enhancing Foods to Protect Health (EFPH) at Purdue University.
Origins and evolution of the Western diet: health implications for the 21st century
http://www.efph.purdue.edu/learning/?loc=publications&pubid=11
Acupuncture Today
Achieving Acid-Base Balance
http://www.acupuncturetoday.com/archives2003/jul/07matesz.html
First Shake.com
Keep reading to find out if you and your family are suffering from low-grade metabolic acidosis and what you can do about it!
http://www.firstshake.com/content.asp?node=83
A NewsTarget Special Report by Jack Challem
The pH Nutrition Guide to Acid / Alkaline Balance
Part 1 - The basic chemistry of pH balance
http://www.newstarget.com/Report_acid_alkaline_pH_1.html
World Health Organization, Food and Agricultural Organization: The roles of calcium and vitamin D in skeletal health: an evolutionary perspective
http://www.fao.org/docrep/W7336T/w7336t03.htm
Publications (selected):
Sebastian A. Thiazides and bone. Am.J.Med. 2000;109:429-30.
Sebastian A, Frassetto L, Sellmeyer D, Morris RCJ. Where's the beef? U.S.News & World Report 2000;BC-63.
Metabolism. In: Academic Press, ed. Nutritional Aspects of Osteoporosis. 2001: Chapter 31. pp. 357-73.
Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC, Jr. Acid-grain: why contemporary diets are net acid-producing. J.Am.Soc.Nephrol. 2001;12:140A (abstr).
Sebastian A, Sellmeyer DE, Stone KL, Cummings SR. Dietary ratio of animal to vegetable protein and rate of bone loss and risk of fracture in postmenopausal women. Am.J Clin.Nutr 2001;74:411-2.
Sebastian A, Frassetto LA, Sellmeyer DE, Morris. RC, Jr. The natural dietary potassium intake of humans exceeds current intakes minimally by a factor of four. J.Am.Soc.Nephrol. 2001;12:40A (abstr).
Sebastian A, Frassetto LA, Sellmeyer DE, Morris R.C. Jr. Diet-induced potassium-replete chloride-sufficient chronic low-grade metabolic alkalosis as the naturally-selected optimal systemic acid-base state of humans. J.Am.Soc.Nephrol. 2001;12:140A (abstr).
Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC, Jr. Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. Am.J.Clin.Nutr. 2002;76:1308-16.
Sebastian A. Low versus high meat diets: effects on calcium metabolism. J Nutr 2003;133:3237-8.
Sebastian A. Estimating Diet Net Acid Load: Reply to T Remer and F Manz [Letter-to-Editor]. Am.J.Clin.Nutr. 2003;78:803-4.
Evolution, diet, acid-base, and bone. The GCRC Journal. 2004.
Sebastian A, Frassetto L, Morris RC, Jr. Authors' Response: Long-Term Persistence of the Urine Calcium-Lowering Effect of Potassium Bicarbonate in Postmenopausal Women [Letter]. J Clin Endocrinol Metab 2005;90:4417-a.
Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J (2005) Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 81:341-354
Frassetto L, Morris RC, Jr., Sebastian A (2005) Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women. J Clin Endocrinol Metab 90:831-834
Hwa C, Sebastian A, Aird WC (2005) Endothelial biomedicine: its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap. Endothelium 12:139-151
Sebastian A (2005) Dietary protein content and the diet's net acid load: opposing effects on bone health. Am J Clin Nutr 82:921-922
Ref ID: 5
Sebastian A (2005) Protein consumption as an important predictor of lower-limb bone mass in elderly women. Am J Clin Nutr 82:1355-1356
Sebastian A, Frassetto LA, Merriam RL, Sellmeyer DE, Morris RC, Jr. An Evolutionary Perspective on the Acid-Base Effects of Diet. In: Gennari FJ, Adrogue HJ, Galla JH, Madias NE, eds. Acid-Base Disorders and Their Treatment. Boca Raton: Taylor and Francis Group 2005:241-92.
Sebastian A, Frassetto LA, Morris RC, Jr. The Acid-Base Effects Of The Contemporary Western Diet: An Evolutionary Perspective. In: Alpern RJ, Hebert SC, eds. The Kidney: Physiology and Pathophysiology. Elsevier 2005.
Sebastian A. Dietary protein content and the diet's net acid load: opposing effects on bone health. Am.J.Clin.Nutr. 2005; In Press.
Sebastian A. Isoflavones, protein, and bone [Editorial]. Am.J.Clin.Nutr. 2005;81:733-5.
Frassetto LA, Morris RC, Jr., Sebastian A (2006) A practical approach to the balance between acid production and renal acid excretion in humans. J Nephrol 19 Suppl 9:S33-S40
Morris RC, Jr., Schmidlin O, Frassetto LA, Sebastian A (2006) Relationship and interaction between sodium and potassium. J Am Coll Nutr 25:262S-270S
Eaton SB, Cordain L, Sebastian A. The Ancestral Biomedical Environment. In: Aird WC, ed. Endothelial Biomedicine. Cambridge: Cambridge University Press 2007:129-34.
Frassetto LA, Morris RC, Jr., Sebastian A. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. Am J Physiol Renal Physiol 2007;293:F521-F525 [http://dx.doi.org/10.1152/ajprenal.00048.2007].
Frassetto LA, Lanham-New SA, Macdonald HM et al. Standardizing Terminology for Estimating the Diet-Dependent Net Acid Load to the Metabolic System. Journal of Nutrition 2007;137:1491-2 [http://jn.nutrition.org]
Schmidlin O, Forman A, Sebastian A, Morris RC, Jr. Sodium-selective salt sensitivity: its occurrence in blacks. Hypertension 2007;50:1085-92.
Schmidlin O, Forman A, Sebastian A, Morris RC, Jr. What initiates the pressor effect of salt in salt-sensitive humans? Observations in normotensive blacks. Hypertension 2007;49:1032-9 [http://hyper.ahajournals.org/cgi/content/abstract/HYPERTENSIONAHA.106.084640v1]
Sebastian A, Frassetto LA, Morris RC, Jr. The Acid-Base Effects of the Contemporary Western Diet: An Evolutionary Perspective. In: Alpern RJ, Hebert SC, eds. The Kidney: Physiology and Pathophysiology. Elsevier 2007:1621-44 [248 references].
Sebastian A, Frassetto LA, Morris RC, Jr. The Acid-Base Effects Of The Contemporary Western Diet: An Evolutionary Perspective. In: Alpern RJ, Hebert SC, eds. The Kidney: Physiology and Pathophysiology. Elsevier 2007.
Frassetto LA, Morris RC, Jr., Sellmeyer DE, Sebastian A. Adverse Effects of Sodium Chloride on Bone in the Aging Human Population Resulting from Habitual Consumption of Typical American Diets. Journal of Nutrition 2008;138:419S-422.
For more publications: PubMed for Sebastian, Anthony
