2008

Hara-Chikuma, M. and A.S. Verkman (2008). Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption. Mol. Cell Biol. 28:328-332

Zador, Z., M. Magzoub, S. Jin, G.T. Manley, M.C. Papadopoulos and A.S. Verkman (2008). Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain. Faseb J. 22:326-332.

Hara-Chikuma, M. and A.S. Verkman (2008). Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing. J. Mol. Med. 86: 221-231.

Ruiz-Ederra, J., H. Zhang and A.S. Verkman (2008). Evidence against functional interaction between aquaporin-4 water channels and Kir4.1 K+ channels in retinal Müller cells. J. Biol. Chem. 282:21866-21872.

Magzoub, M., S. Jin and A.S. Verkman (2008). Enhanced macromolecule diffusion deep in tumors after enzymatic degradation of extracellular matrix collagen and its associated proteoglycan decorin. Faseb J. 22:276-284.

Saadoun, S., B.A. Bell, A.S. Verkman and M.C. Papadopoulos (2008). Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain 131:1087-1098.

Zhang, H. and A.S. Verkman (2008). Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells. Mol. Cell Neurosci. 37:1-10.

Yang, B., N.D. Sonawane, D. Zhao, S. Somlo and A.S. Verkman (2008). Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. J. Am. Soc. Nephrol. 19:1300-1310.

Crane, J. and A.S. Verkman (2008). Long-range non-anomalous diffusion of quantum dot-labeled aquaporin-1 water channels in the cell plasma membrane. Biophys. J. 94:702-713.

De La Fuente, R., W. Namkung, A. Mills and A.S. Verkman (2008). Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol. Pharmacol. 73:758-768.

Jin, S., Z. Zador and A.S. Verkman (2008). Random-walk model of diffusion in 3-dimensions in brain extracellular space: comparison with microfiberoptic photobleaching measurements. Biophys. J. 95:1785-1794.

Sonawane, N., D. Zhao, O. Zegarra-Mora, L.J.V. Galietta and A.S. Verkman (2008). Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides. Chem. Biol. 15:718-728.

Sonawane, N., O. Zegarra-Mora, L.J.V. Galietta and A.S. Verkman (2008). α-Aminoazaheterocyclic-methylglyoxyl adducts do not inhibit cystic fibrosis transmembrane conductance chloride channel activity. J. Pharm. Exper. Therapeut. 325:529-535.

Yang, B., Z. Zador and A.S. Verkman (2008). Glial cell AQP4 overexpression in transgenic mice accelerates cytotoxic brain swelling. J. Biol. Chem. 283:15280-15286.

Yoo, C.L., G.J. Yu, B. Yang, L.I. Robins, A.S. Verkman and M.J. Kurth (2008). 4'-Methyl-4,5'-bithiazole-based correctors of defective ΔF508-CFTR cellular processing. Bioorg. Med. Chem. Lett. 18:2610-2614.

Sonawane, N. and A.S. Verkman (2008). Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis. Bioorg. Med. Chem. In press.

Namkung, W., P. Padmawar, A.D. Mills and A.S. Verkman (2008). Fluorescence cell-based screen for K+ channels and transporters using an extracellular triazacryptand-based K+ indicator. J. Am. Chem. Soc. 130:7794-7795.

Crane, J., W.R. Skach, A.N. van Hoek and A.S. Verkman (2008). Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking. Mol. Biol. Cell 19:3369-3378.

Yang, B., H. Zhang and A.S. Verkman (2008). Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides. Bioorg. Med. Chem. 16:7489-7493.

Yu, G.J., C.L. Yoo, B. Yang, L. Meng, T.T. El-Idressy, J.C. Fettinger, A.S. Verkman and M.J. Kurth (2008). Potent c-cis-locked bithiazol correctors of ΔF508-CFTR cellular processing for cystic fibrosis therapy. J. Med. Chem. In press.

Lu, D., H. Zhang, Z. Zador and A.S. Verkman (2008). Impaired olfaction in mice lacking aquaporin-4 water channels. Faseb J. In press.

Zhang, H. and A.S. Verkman (2008). Evidence against involvement of aquaporin-4 in cell-cell adhesion. J. Mol. Biol. In press.

Haggie, P.H. and A.S. Verkman (2008). Monomeric CFTR in plasma membranes in live cells revealed by single-molecule fluorescence imaging. J. Biol. Chem. In press (accelerated publication)

Tradtrantip, L., B. Yangthara, P. Padmawar, C. Morrison and A.S. Verkman (2008). Thiophenecarboxylate suppressor of cyclic nucleotide discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion. Mol. Pharmacol. In press.

2008 Reviews

Dix, J.A. and A.S. Verkman (2008). Crowding effects on diffusion in solution and cells. Annu. Rev. Biophys. 37:247-263.

Papadopoulos, M.C., S. Saadoun and A.S. Verkman (2008). Aquaporins and cell migration. Pflugers Arch. 456:693-700.

Papadopoulos, M.C. and A.S. Verkman (2008). Potential utility of aquaporin modulators for therapy of brain disorders. Prog. Brain Res. 170:589-601.

Verkman, A.S. (2008). Knockout models reveal new aquaporin functions. In: Aquaporins, E. Beitz, ed. Springer. Handbook of Experimental Pharmacology Series. In press.

Verkman, A.S. (2008). Dissecting the role of aquaporins in renal pathophysiology using transgenic mice. Semin. Nephrol. 28:217-226.

Verkman, A.S., M. Hara-Chikuma and M.C. Papadopoulos (2008). Aquaporins — new players in cancer biology. J. Mol. Med. 86:523-529.

Verkman, A.S. (2008). A cautionary note on cosmetics containing ingredients that increase aquaporin-3 expression. Exper. Dermatol. In press.

Hara-Chikuma, M. and A.S. Verkman (2008). Roles of aquaporin-3 in epidermis. J. Invest. Dermatol. 128:2145-2151.

A.S. Verkman, J. Ruiz-Ederra and M. Levin (2008). Functions of aquaporins in the eye. Prog. Ret. Eye Res. 27:420-433.

Verkman, A.S. (2008). Mammalian aquaporins: diverse physiological roles and potential clinical significance. Expert Rev. Mol. Med. 10:e13.

Verkman, A.S. (2008). From the farm to the lab: the pig as a new model of cystic fibrosis lung disease. Am. J. Physiol. 295:L238-L239.

Verkman, A.S. (2008). Chemical and GFP-based fluorescent chloride indicators. For: Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Disease. F.J. Alvarez-Leefmans and E. Delpire, eds. Elsevier. In press.

Verkman, A.S. (2008). Aquaporins: translating bench research to human disease. J. Exp. Biol. In press.

2007

Yangthara, B., A. Mills, V. Chatsudthiapong, L. Tradtrantip and A.S. Verkman (2007). Small-molecule vasopressin-2 receptor antagonist identified by a G-protein coupled receptor 'pathway' screen. Mol. Pharmacol. 72:86-94.

Jin, S. and A.S. Verkman (2007). Single particle tracking simulations of complex diffusion in membranes: simulation and detection of barrier, raft, and interaction phenomena. J. Phys. Chem. B 111:3625-3632.

Thiagarajah, J.R., D. Zhao and A.S. Verkman (2007). Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis. Gut 56:1529-1535.

Auguste, K., S. Jin, K. Uchida, D. Yan, G.T. Manley, M.C. Papadopoulos and A.S. Verkman (2007). Greatly impaired migration of implanted aquaporin-4 deficient astroglial cells in mouse brain toward a site of injury. Faseb J. 21:108-116

Ruiz-Ederra, J., and A.S. Verkman (2007). Aquaporin-1 independent microvessel proliferation in a neonatal mouse model of oxygen induced retinopathy. Invest. Opthalmol. Vis. Sci. 48:4802-4810.

Levin, M.H., R. de la Fuente and A.S. Verkman (2007). Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B. Faseb J. 21:551-563.

Jin, S., P.M. Haggie and A.S. Verkman (2007). Single particle tracking analysis of membrane protein diffusion in a potential: simulation and application to confined diffusion of CFTR Cl- channels. Biophys. J. 93:1079-1088.

Haggie, P.M. and A.S. Verkman (2007). Unimpaired phagolysosomal acidification in alveolar macrophages in cystic fibrosis. J. Biol. Chem. 282:31422-31428.

Sonawane, N., D. Zhao, O. Zegarra-Mora, L.J.V. Galietta and A.S. Verkman (2007). Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology 132:1234-1244.

2007 Reviews

Papadopoulos, M.C., S. Saadoun, and A.S. Verkman (2007). Aquaporins in the central nervous system. In: Handbook of Neurochemistry and Molecular Neurobiology. Springer. In press.

Verkman, A.S. (2007). Aquaporins and water transport across the cornea. In: Ocular Transporters in Disease and Drug Delivery. J. Tombran-Tink and C.J. Barnstable, eds. Humana Press. In press.

Papadopoulos, M.C., and A.S. Verkman (2007). Aquaporin-4 and brain edema. Ped. Nephrol. 22:778-784.

Verkman A.S. (2007). Role of aquaporins in lung fluid physiology. Resp. Physiol. Neurobiol. 159:324-330.

2006

Sonawane, N.D., J. Hu, C. Muanprasat and A.S. Verkman (2006). Luminally-active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid losses in cholera. Faseb J. 20:130-132.

Levin, M.H., J.K. Kim, J. Hu and A.S. Verkman (2006). Potential difference measurements of ocular surface Na+ absorption analyzed using an electrokinetic model. Invest. Opthalmol. Vis. Sci. 47:306-316.

Bloch, O., G.T. Manley and A.S. Verkman (2006). Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4 deficient mice. J. Cereb. Bood Flow Metab. 26:1527-1537.

Oshio, K., H. Watanabe, D. Yan, A.S. Verkman and G.T. Manley (2006). Impaired pain sensation in mice lacking aquaporin-1 water channels. Biochim. Biophys. Res. Comm. 341:1022-1028

Dix, J.A., E.F.Y. Hom and A.S. Verkman (2006). Fluorescence correlation spectroscopy simulations of photophysical phenomena and macromolecular interactions: A molecule dynamics/Monte-Carlo approach. J. Phys. Chem. B. 110:1896-1906.

Hara-Chikuma, M. and A.S. Verkman (2006). Aquaporin-1 facilitates epithelial cell migration in kidney proximal tubule. J. Am. Soc. Nephrol. 17:39-45.

Ruiz-Ederra, J. and A.S. Verkman (2006). Mouse model of sustained elevation in intraocular pressure produced by episcleral vein occlusion. Exper. Eye Res. 82:879-884.

Song, Y., D. Salinas, D.W. Nielson and A.S. Verkman (2006). Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis. Am. J. Physiol. 290:C741-749.

Hu, J., and A.S. Verkman (2006). Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. Faseb J. 20:1892-1894.

Binder, D.K., X. Yao, T.J. Sick, A.S. Verkman and G.T. Manley (2006). Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia 53:631-636.

Thiagarajah, J.R., J.K. Kim, M. Magzoub, and A.S. Verkman (2006). Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. Nature Meth. 3:275-280.

Yang, B., D. Zhou, L. Qain, and A.S. Verkman (2006). Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am. J. Physiol. 291:F465-F472.

Yang, B., D. Zhao, E. Solenov, and A.S. Verkman (2006). Evidence from knockout mice against physiologically significant aquaporin-8 facilitated ammonia transport. Am. J. Physiol. 291:C417-C423.

Levin, M.H., and A.S. Verkman (2006). Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization. Invest. Opthalmol. Vis. Sci. 47: 4365-4372.

Ruiz-Ederra, J., and A.S. Verkman (2006). Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice. Invest. Opthalmol. Vis. Sci. 47:3960-3967.

Yang, B., J.K. Kim and A.S. Verkman (2006). Comparative efficacy of HgCl2 with candidate aquaporin-1 inhibitors DMSO, gold, TEA+ and acetazolamide. FEBS Lett. 580:6679-6684.

De La Fuente, R., D. Arumainayagam, N.D. Sonawane, and A.S. Verkman (2006). Small-molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening. Br. J. Pharmacol. 149:551-559.

Yang, B., D. Zhao, and A.S. Verkman (2006). Evidence against functionally significant aquaporin expression in mitochondria. J. Biol. Chem. 281:16202-16206.

Magzoub, M., P. Padmawar, J.A. Dix, and A.S. Verkman (2006). Millisecond association kinetics of K+ with triazacryptand-based K+ indicators measured by fluorescence correlation spectroscopy. J. Phys. Chem. B. 110:21216-21221.

Haggie, P.M., J.K. Kim, G.L. Lukacs, and A.S. Verkman (2006). Tracking of quantum dot-labeled CFTR shows near immobilization at the plasma membrane by C-terminal PDZ interactions. Mol. Biol. Cell 17:4937-4945

Levin, M.H., S. Sullivan, D. Nielson, B. Yang, W.E. Finkbeiner and A.S. Verkman (2006). Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins. J. Biol. Chem. 281:25803-25812.

2006 Reviews

Verkman, A.S. and J.R. Thiagarajah (2006). Physiology of water transport in the gastrointestinal tract. In: Physiology of the Gastrointestinal Tract. L.R. Johnson, K. Barrett, F. Ghishan, J. Manchant, H. Said, J. Wood, eds. Vol. 4, New York, Academic Press, p. 1827-1845.

Verkman, A.S., G.L. Lukacs and L.J. Galietta (2006). CFTR chloride channel drug discovery - inhibitors as antidiarrheals and activators for therapy of cystic fibrosis. Curr. Pharm. Des. 12:2235-2247.

Verkman, A.S. and L.J. Galietta (2006). In vitro/ex vivo fluorescence assays of chloride channel function. In: Cystic Fibrosis in the 21st Century: Progress in Respiratory Research. Eds. A. Bush, E. Alton, J. Davies, J. Griesenbach and A. Jaffe. 34:93-101.

Levin, M.H. and A.S. Verkman (2006). Aquaporins and CFTR in ocular epithelial fluid transport. J. Memb. Biol. 210:105-115

Verkman, A.S. and Y.L. Song (2006). Role of aquaporin water channels in lung and airways. In: Encyclopedia of Respiratory Medicine. G.J. Laurent and S.D. Shapiro, Eds. Elsevier. P. 140-143.

Verkman, A.S. (2006). Aquaporins in endothelia. Kid. Internat. 69:1120-1123.

Verkman, A.S., D.K. Binder, O. Bloch, K. Auguste, and M.C. Papadopoulos (2006). Three distinct roles of aquaporin-4 in brain function revealed by knockout mice. Biochem. Biophys. Acta. 1758:1085-1093.

Verkman, A.S. (2006). Roles of aquaporins in kidney revealed by transgenic mice. Semin. Nephrol. 26:200-208.

Hara-Chikuma, M. and A.S. Verkman (2006). Physiological roles of glycerol-transporting aquaporins — the aquaglyeroporins. Cell Mol. Life Sci. 63:1386-1392.

2005

Salinas, D., P.M. Haggie, J.R. Thiagarajah, Y. Song, K. Rosby, W.F. Finkbeiner, D.W. Nielson and A.S. Verkman (2005). Submucosal gland dysfuction as a primary defect in cystic fibrosis. Faseb J. 19:431-433.

Levin, M.H. and A.S. Verkman (2005). CFTR-regulated chloride transport at the ocular surface in living mice measured by potential differences. Invest. Opthalmol. Vis. Sci. 46:1428-1434.

Sonawane, N.D., Muanprasat, C., Nagatani, R., Y. Song and A.S. Verkman (2005). In vivo pharmacology and antidiarrheal efficacy of a thiazolidinone CFTR inhibitor in rodents. J. Pharm. Sci. 94:134-143.

Papadopoulos, M.C., D. Binder and A.S. Verkman (2005). Expansion of brain extracellular space in mouse models of vasogenic brain edema: in vivo measurement by cortical surface photobleaching. Faseb J. 19:425-427.

Papadopoulos, M.C., and A.S. Verkman (2005). Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J. Biol. Chem. 280:13906-13912.

Hara-Chikuma, M., B. Yang, N.D. Sonawane, S. Sasaki, S. Uchida, and A.S. Verkman (2005). ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation. J. Biol. Chem. 280:1241-1247.

Saadoun, S., M.C. Papadopoulos, M. Hara-Chikuma and A.S. Verkman (2005). Impairment of angiogenesis and cell migration by targeted of aquaporin-1 gene disruption. Nature 434:786-792.

Papadopoulos, M.C., J.K. Kim and A.S. Verkman (2005). Extracellular space diffusion in central nervous system: anisotropic diffusion measured by elliptical surface photobleaching. Biophys. J. 89:3660-3668.

Thiagarajah, J.R., M.C. Papadopoulos and A.S. Verkman (2005). Non-invasive early detection of brain edema in mice by near-infrared light scattering. J. Neurosci. Res. 80:293-299.

Yang, B., Y. Song, D. Zhao, and A.S. Verkman (2005). Phenotype analysis of aquaporin-8 deficient mice. Am. J. Physiol. 288:C1161-C1170.

Sohara, E., T. Rai, J. Miyazaki, A.S. Verkman, S. Sasaki, and S. Uchida (2005). Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am. J. Physiol. 289:F1195-F1200.

Dauty, E. and A.S. Verkman (2005). Actin cytoskeleton as the principal determinant of size-dependent DNA mobility in cytoplasm: a new barrier for non-viral gene delivery. J. Biol. Chem. 280:7823-7828.

Oshio, K., Y. Song, A.S. Verkman and G.T. Manley (2005). Reduced intraventricular pressure and cerebrospinal fluid production in mice lacking aquaporin-1 water channels. Faseb J. 18:76-78.

Pedemonte, N., N.D. Sonawane, A. Taddei, J. Hu, O. Zegarra-Moran, Y.F. Suen, L.I. Robins, C.W. Dicus, D. Willenbring, M.H. Nantz, M.J. Kurth, L.J. Galietta and A.S. Verkman (2005). Phenylglycine and sulfonamide correctors of defective ΔF508- and G551D-CFTR chloride channel gating. Mol. Pharmacol. 67:1797-1807.

Hara-Chikuma, M., E. Sohara, T. Rai, M. Ikawa, M. Okabe, S. Sasaki, S. Uchida and A.S. Verkman (2005). Progressive adipocyte hypertrophy in aquaporin-7 deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J. Biol. Chem. 280:15493-15496. (accelerated publication)

Hara-Chikuma, M., Y. Wang, S.E. Guggino, W.B. Guggino and A.S. Verkman (2005). Impaired acidification in early endosomes of ClC-5 deficient proximal tubule. Biochem. Biophys. Res. Comm. 329:941-946.

Pedemonte, N., G.L. Lukacs, K. Du, E. Caci, O. Zegarra-Moran, L.J. Galietta and A.S. Verkman (2005). Small molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening. J. Clin. Invest. 115:2564-2571.

Bloch, O., M.C. Papadopoulos, G.T. Manley and A.S. Verkman (2005). Aquaporin-4 gene deletion in mice increases focal edema associated with brain abscess. J. Neurochem. 95:254-262.

Lennon, V.A., T.J. Kryzer, S.J. Pittock, A.S. Verkman, and S.R. Hinson (2005). IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J. Exp. Med. 202:473-477.

Morishita, Y., T. Matsuzaki, M. Hara-Chikuma, A. Andoo, M. Shimono, A. Matsuki, K. Kobayashi, M. Ikeda, T. Yamamoto, A.S. Verkman, E. Kusano, S. Ookawara, K. Takata, S. Sasaki, and K. Ishibashi (2005). Disruption of aquaporin-11 produced polycystic kidneys following vacuolization of the proximal tubule. Mol. Cell Biol. 25:7770-7779.

Padmawar, P., X. Yao, O. Bloch, G.T. Manley and A.S. Verkman (2005). K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator. Nature Meth. 2:825-827.

Saadoun, M., M.C. Papadopoulos, H. Watanabe, D. Yan, G.T. Manley and A.S. Verkman (2005). Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J. Cell Sci. 118:5691-5698.

2005 Reviews

Haggie, P.H. and A.S. Verkman (2005). Green fluorescent protein sensors. In: Advanced Topics in Fluorescence Spectroscopy: Curr. Topics Fluores. Eds. C.D. Geddes and J.R. Lakowicz, 10:21-40.

Hara-Chikuma, M. and A.S. Verkman (2005). AQP3 functions as a glycerol transporter in mammalian skin. Biol. Cell 97:479-486.

Lechardeur, D., A.S. Verkman and G.L. Lukacs (2005). Intracellular routing of plasmid DNA during non-viral gene transfer. Adv. Drug Deliv. Rev. 57:755-767.

Lechardeur, D., A.S. Verkman, and G.L. Lukacs (2005). Intracellular routing of plasmid DNA during non-viral gene transfer. Adv. Drug Deliv. Rev. 57:755-767.

Thiagarajah, J.R., and A.S. Verkman (2005). New drug targets for cholera therapy. Trends. Pharm. Sci. 26:172-175.

Verkman, A.S. (2005). Novel roles of aquaporins revealed by phenotype analysis of knockout mice. Rev. Physiol. Biochem. Pharmacol. 155:31-55.

Verkman, A.S. (2005). More than just water channels: unexpected cellular roles of aquaporins. J. Cell Sci. 118:3225-3232.

2004

Haggie, P.H., B.A. Stanton and A.S. Verkman (2004). Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminus PDZ-binding motif. J. Biol. Chem. 279:5494-5500.

Thiagarajah, J., T. Broadbent, E. Hsieh and A.S. Verkman (2004). Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Gastroenterology 126:511-519.

Binder, D., K. Oshio, T. Ma, A.S. Verkman and G.T. Manley (2004). Increased seizure threshold in mice deficient in aquaporin-4 water channels. Neuroreport 15:259-262.

Solenov, E., H. Watanabe, G.T. Manley and A.S. Verkman (2004). Seven-fold reduced osmotic water permeability in primary astrocyte cultures from aquaporin-4 deficient mice measured by a fluorescence quenching method. Am. J. Physiol. 286:C426-C432.

Dauty, E. and A.S. Verkman (2004). Macromolecular crowding reduces to a similar extent the diffusion of small solutes and macromolcules: measurement by fluorescence correlation spectroscopy. J. Mol. Recog. 17:441-447.

Taddei, A., C. Folli, O. Zegarra-Moran, P. Fanen, A.S. Verkman and L.J. Galietta (2004). Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 558:52-56.

Salinas, D.B., N. Pedemonte, C. Muanprasat, W.F. Finkbeiner, D.W. Nielson and A.S. Verkman (2004). CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor. Am. J. Physiol. 287:L936-L943.

Oshio, K., D.K. Binder, B. Yang, S. Schecter, A.S. Verkman and G.T. Manley. (2004). Expression of aquaporin water channels in mouse spinal cord. Neurosci. 127:685-693.

Thiagarajah, J.R., Y. Song, P. Haggie and A.S. Verkman (2004). A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. Faseb J. 18:875-877.

Papadopoulos, M.C., S. Krishna, G.T. Manley and A.S. Verkman (2004). Aquaporin-4 facilitates the reabsorption of excess fluid in vasogenic brain edema. Faseb J. 18:1291-1293.

Binder, D., M.C. Papadopolous, P.M. Haggie and A.S. Verkman (2004). In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. J. Neurosci. 24:8049-8056.

Muanprasat, C., N.D. Sonawane, D. Salinas, A. Taddei, L.J.V. Galietta and A.S. Verkman (2004). Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis and in vivo efficacy. J. Gen. Physiol. 124:125-137.

Da, T. and A.S. Verkman (2004). Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia. Invest. Opthalmol. Vis. Sci. 45:4477-4483.

Levin, M.H. and A.S. Verkman (2004). Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva. Invest. Opthalmol. Vis. Sci. 45:4423-4432.

Song, Y., N.D. Sonawane, D. Salinas, L. Qian, N. Pedemonte, L.J. Galietta and A.S. Verkman (2004). Evidence against rescue of defective ΔF508-CFTR cellular processing by curcumin in cell culture and mouse models. J. Biol. Chem. 279:40629-40633.

2004 Reviews

Verkman, A.S., P.H. Haggie and L.J. Galietta (2004). Application of green fluorescent protein-based chloride indicators for drug discovery by high-throughput screening. Ann. Rev. Fluores. In press.

Verkman, A.S. (2004). Drug discovery in academia. Am. J. Physiol. 286:C465-C474.

Verkman, A.S. (2004). Drug discovery and epithelial physiology. Curr. Opin. Nephrol. Hyperten. 13:563-568.

Smart, T., J. Peters, F. Ashcroft, C. Miller, M. Sanguinetti, D. Clapham, D. Dougherty, S. Lummis, F. Bezanilla, S. Choe, D. Benos, K. Chien, W. Stuhmer, R. Lewis, M. Lazdunski, B. Liss, T. Smart, R. Lewis, A.S. Verkman, J. Vandenberg, A. North, C. Miller, I. Levitan, and J. Peters (2004). The nature reviews drug discovery ion channel questionnaire participants. Nature Rev. Drug. Discov. 3:239-278.

Papadopoulos, M.C., S. Saadoun, D.K. Binder, G.T. Manley, S. Krishna and A.S. Verkman (2004). Molecular mechanisms of brain tumor edema. Neurosci. 129:1009-1018.

Manley, G.T., D.K. Binder, M. Papadopoulos and A.S. Verkman (2004). Phenotype analysis of AQP4 null mice: new insights into the mechanisms of water transport and edema in the nervous system. Neurosci. 129:981-989.

2003

Jiang, J., Y. Song, C. Bai, B.H. Koller, M.A. Matthay and A.S. Verkman (2003). Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. J. Appl. Physiol. 94:343-352.

Sonawane, N. and A.S. Verkman (2003). Determinants of [Cl-] in recycling and late endosomes and Golgi complex measured using fluorescent ligands. J. Cell Biol. 160:1129-1138.

Song, Y., J. Thiagarajah and A.S. Verkman (2003). Ionic concentrations, pH and depth of airway surface liquid in distal airways. J. Gen. Physiol. 122:511-519.

Hara, M. and A.S. Verkman (2003). Glycerol replacement corrects defective skin hydration, elasticity and barrier function in mice lacking aquaporin-3. Proc. Natl. Acad. Sci. U.S.A. 100:7360-7365.

Yang, H., A.A. Shelat, R.K. Guy, V.S. Gopinath, T. Ma, K. Du, G.L. Lukacs, A. Taddei, C. Folli, N. Pedemonte, L.V. Galietta and A.S. Verkman (2003). Nanomolar affinity small-molecule correctors of defective ΔF508-CFTR chloride channel gating. J. Biol. Chem. 278:35079-35085.

Caci, E., C. Folli, O. Zegarra-Moran, T. Ma, M.F. Springsteel, R.E. Sammelson, M.H. Nantz, M.J. Kurth, A.S. Verkman and L.J. Galietta (2003). CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am. J. Physiol. 285:L180-L188.

Sammelson, R.E., T. Ma, L.J. Galietta, A.S. Verkman and M.J. Kurth (2003). 3-(2-benzyloxyphenyl) isoxazoles and isoxazolines: Synthesis and evaluation as CFTR activators. Bioorgan. Med. Chem. Lett. 13:2509-2512.

Sonawane, N., F.C. Szoka and A.S. Verkman (2003). Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J. Biol. Chem. 278:44826-44831.

2003 Reviews

Verkman, A.S., Y. Song and J. Thiagarajah (2003). Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease. Am. J. Physiol. 284:C2-C15.

Verkman, A.S. (2003). Role of aquaporin water channels in eye function. Exp. Eye Res. 76:137-143.

Verkman, A.S. (2003). Diffusion in cells measured by fluorescence recovery after photobleaching. Meth. Enzymol. 360:635-648.

Thiagarajah, J.R. and A.S. Verkman (2003). CFTR pharmacology and its role in intestinal fluid secretion. Curr. Opin. Pharm. 3:594-599.

2002

Solenov, E.I., L. Vetrivel, K. Oshio, G.T. Manley and A.S. Verkman (2002). Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice. J. Neurosci. Methods 113:85-90.

Fang, X., B. Yang, M.A. Matthay, and A.S. Verkman (2002). Evidence against aquaporin dependent CO2 permeability in lung and kidney. J. Physiol. (London) 543:63-69.

Li, J., R.V. Patil and A.S. Verkman (2002). Mildly abnormal retinal function in transgenic mice lacking aquaporin-4 water channels. Invest. Opthal. Vis. Sci. 43:573-579.

Zhang, D., L. Vetrivel and A.S. Verkman (2002). Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production. J. Gen. Physiol. 119:561-569.

Sonawane, N., J.R. Thiagarajah and A.S. Verkman (2002). Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: evidence for Cl- accumulation during acidification. J. Biol. Chem. 277:5506-5513.

Haggie, P.M., B.A. Stanton and A.S. Verkman (2002). Diffusional mobility of ΔF508-CFTR in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras. J. Biol. Chem. 277:16419-16425

Yang, B., L. Bankir, A. Gillespie, C.J. Epstein and A.S. Verkman (2002). Urea-selective urinary concentrating defect in transgenic mice lacking urea transporter UT-B. J. Biol. Chem. 277:10633-10637.

Song, Y., N. Sonawane and A.S. Verkman (2002). Localization of aquaporin-5 in sweat gland and functional analysis using knockout mice. J. Physiol. 541:561-568.

Hom, E.F. and A.S. Verkman (2002). Analysis of coupled bimolecular reaction kinetics and diffusion by 2-color fluorescence correlation spectroscopy: enhanced resolution of kinetics by resonance energy transfer. Biophys. J. 83:533-546.

Ma, T., M. Hara, R. Sougrat, J.M. Verbavatz and A.S. Verkman (2002). Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. J. Biol. Chem. 277:17147-17153.

Haggie, P. and A.S. Verkman (2002). Diffusion of tricarboxylic acid cycle enzymes in the mitochondrial matrix in vivo: Evidence for restricted mobility of a multienzyme complex. J. Biol. Chem. 277:40782-40788.

Thiagarajah, J.R. and A.S. Verkman (2002). Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. J. Biol. Chem. 277:19139-19144.

Yang, B. and A.S. Verkman (2002). Analysis of double knockout mice lacking water channel aquaporin-1 and urea transporter UT-B: Evidence for UT-B facilitated water transport in erythrocytes. J. Biol. Chem. 277:36782-36786.

Hara, M., T. Ma and A.S. Verkman (2002). Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration, elasticity and barrier recovery. J. Biol. Chem. 277:46616-46621.

Ma, T., L. Vetrivel, H. Yang, N. Pedemonte, N. Zegarra-Moran, L.J.V. Galietta and A.S. Verkman (2002). High-affinity activators of CFTR chloride conductance identified by high-throughput screening. J. Biol. Chem. 277:37235-37241.

Ma, T., J.R. Thiagarajah, H. Yang, N.D. Sonawane, C. Folli, L.J. Galietta and A.S. Verkman (2002). Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera-toxin induced intestinal fluid secretion. J. Clin. Invest. 110:1651-1658.

2002 Reviews

Verkman, A.S. and B. Yang (2002). Aquaporin gene delivery to kidney. Kid. Internat. 61 (Suppl 1):120-124.

Verkman, A.S. (2002). Solute and macromolecule diffusion in aqueous compartments of living cells. Trends Biochem. Sci. 27:27-33.

Verkman, A.S. and S. Jayaraman (2002). Fluorescent indicator methods to assay functional CFTR expression in cells. Methods Mol. Med. 70:187-196.

Borok, Z. and A.S. Verkman (2002). Lung edema clearance: 20 years of progress: Invited review: Role of aquaporin water channels in fluid transport in lung and airways. J. Appl. Physiol. 93:2199-2206.

Verkman, A.S. (2002). Physiological importance of aquaporin water channels. Annals Med. 34:192-200.

Papadopoulos, M.C., S. Krishna and A.S. Verkman (2002). Aquaporin water channels and brain edema. Mt. Sinai J. Med. 69:242-248.

Verkman, A.S. (2002). Renal concentrating and diluting function in deficiency of specific aquaporin genes. Exper. Nephrol. 10:235-240.

Verkman, A.S. (2002). Does aquaporin-1 pass gas? An opposing view. J. Physiol. (London) 542:31.

Verkman, A.S. (2002). Aquaporin water channels and endothelial cell function. J. Anatomy 200:617-627.

2001

Jayaraman, S., Y. Song, L. Vetrivel, L. Shankar and A.S. Verkman (2001). Non-invasive in vivo fluorescence measurement of airway surface liquid depth, salt concentration, and pH. J. Clin. Invest. 107:317-324.

Yang, B., A. Gillespie, E.J. Carlson, C.J. Epstein and A.S. Verkman (2001). Neonatal mortality in a transgenic AQP2 knock-in model of nephrogenic diabetes insipidus. J. Biol. Chem. 276:2775-2779.

Yang, B., T. Ma and A.S. Verkman (2001). Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J. Biol. Chem. 276:624-628.

Jayaraman, Y. Song and A.S. Verkman (2001). Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea. Am. J. Physiol. 281:C1504-C1511.

Jayaraman, Y. Song and A.S. Verkman (2001). Airway surface liquid osmolality measured using fluorophore-encapsulted liposomes. J. Gen. Physiol. 117:423-430.

Jayaraman, N.S. Joo, B. Reitz, J.J. Wine and A.S. Verkman (2001). Submucosal gland secretions in airways from cystic fibrosis patients have normal salt and pH but elevated viscosity. Proc. Natl. Acad. Sci. U.S.A. 98:8119-8123.

Levin, M.H., P.M. Haggie, L. Vetrivel and A.S. Verkman (2001). Diffusion in the endoplasmic reticulum of an aquaporin-2 mutant causing human nephrogenic diabetes insipidus. J. Biol. Chem. 276:21331-21336.

Galietta, L.J.V., P.M. Haggie and A.S. Verkman (2001). Green fluorescent protein-based halide indicators with improved chloride and iodide affinities. FEBS Lett. 499:220-224.

Galietta, L.J.V., M.F. Springsteel, M. Eda, E.J. Niedzinski, K. By, M.J. Haddadin, M.J. Kurth, M.H. Nantz and A.S. Verkman (2001). Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. J. Biol. Chem. 276:19723-19728.

Galietta, L.J.V., S. Jayaraman and A.S. Verkman (2001). Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. Am. J. Physiol. 281:C1734-C1742.

Song, Y., S. Jayaraman, B. Yang, M.A. Matthay and A.S. Verkman (2001). Role of aquaporin water channels in airway fluid transport, humidification and surface liquid hydration. J. Gen. Physiol. 117:573-582.

Thiagarajah, J.R., S. Jayaraman, R.J. Naftalin and A.S. Verkman (2001). In vivo fluorescence measurement of Na+ concentration in the pericryptal space of mouse descending colon: direct evidence for accumulation of a hypertonic absorbate. Am. J. Physiol. 281:C1898-C1903.

Li, J. and A.S. Verkman (2001). Impaired hearing in mice lacking aquaporin-4 water channels. J. Biol. Chem. 276:31233-31237.

Song, Y. and A.S. Verkman (2001). Aquaporin-5 dependent fluid secretion in airway submucosal glands. J. Biol. Chem. 276:41288-41292.

2001 Reviews

Verkman, A.S., L. Vetrivel and P. Haggie (2001). Diffusion measurements by photobleaching recovery methods. In: Methods in Cellular Imaging. A. Periasamy, ed. Oxford University Press. p. 112-127.

Verkman, A.S., B. Yang, W.R. Skach, A. Mitra, Y. Song, G.T. Manley and T. Ma (2001). Genetic and biophysical approaches to study water channel biology. In: Current topics in membranes. Vol. 51. Water channels. J. Hohmann, P. Agre and S. Nielsen, Eds. Academic Press. p. 185-233.

Verkman, A.S., J. Li, T. Ma and B. Yang. (2001). Role of aquaporin water channels in kidney function studied using transgenic mice. Clin. Exper. Nephrol. 5:75-84.

Ma, T. and A.S. Verkman (2001) Gastrointestinal phenotype of aquaporin knockout mice. In: Molecular biology and physiology of water and solute transport. S. Hohmann and S. Nielsen, Eds. Klewer Academic/Plenum Pub. p. 151-157.

Verkman, A.S. (2001). Lung disease in cystic fibrosis: Is airway surface liquid composition abnormal? Am. J. Physiol. 281:L306-L308.

Verkman, A.S., J. Li, D. Zhang, B. Yang, T. Ma, G.T. Manley, and Y. Song. (2001). Phenotype analysis of aquaporin transgenic mice. Bull. Mol. Med. 7:3-16.

Verkman, A.S. (2001). Potential utility of aquaporin blockers as aquaretics. Drug News & Perspectives. 14:412-420.

2000

Umenishi, F., J.M. Verbavatz and A.S. Verkman (2000). cAMP regulated membrane diffusion of a green fluorescent protein-aquaporin-2 chimera measured by photobleaching recovery. Biophys. J. 78:1024-1035.

Yang, B., T. Ma. J.Y. Dong and A.S. Verkman (2000). Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Human Gene Therapy 11:567-575.

Song, Y., T. Ma, M.A. Matthay and A.S. Verkman (2000). Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J. Gen. Physiol. 115:17-27.

Pallone, T.L., A. Edwards, T. Ma, E. Silldorff and A.S. Verkman (2000). Requirement of aquaporin-1 for NaCl driven water transport across descending vasa recta. J. Clin. Invest. 105:215-222.

Manley, G.T., M. Fujimura, T. Ma, N. Noshita, F. Filiz, A. Bollen, P. Chan and A.S. Verkman (2000). Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nature Medicine 6:159-163.

Ma, T., N. Fukuda, Y. Song, M.A. Matthay and A.S. Verkman (2000). Lung fluid transport in aquaporin-5 knockout mice. J. Clin. Invest. 105:93-100.

Yang, B., N. Fukuda, A.N. van Hoek, M.A. Matthay, T. Ma and A.S. Verkman (2000). Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J. Biol. Chem. 275:2686-2692.

Lukacs, G., P. Haggie, O. Seksek, D. Lechardeur, N. Freedman and A.S. Verkman (2000). Size-dependent DNA mobility in cytoplasm and nucleus. J. Biol. Chem. 275:1625-1629.

Moore, M., T. Ma, B. Yang and A.S. Verkman (2000). Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp. Eye Res. 70:557-562.

Yang, B., J.M. Verbavatz, Y. Song, G. Manley, L. Vetrivel, W.M. Kao, T. Ma and A.S. Verkman (2000). Skeletal muscle function and water transport in aquaporin-4 deficient mice. Am. J. Physiol. 278:C1008-C1115.

Jayaraman, S., P. Haggie, R. Wachter, S.J. Remington and A.S. Verkman (2000). Mechanism and cellular applications of a green fluorescent protein-based halide sensor. J. Biol. Chem. 275:6047-6050. (accelerated publication)

Wang, K.S., A.R. Komar, T. Ma, F. Filiz, J. McLeroy, K. Hoda, A.S. Verkman and J.A. Bastidas (2000). Gastric acid secretion in aquaporin-4 knockout mice. Am. J. Physiol. 279:G448-G453.

Vallon, V., A.S. Verkman and J. Schnermann (2000). Luminal hypotonicity in proximal tubules of aquaporin-1 knockout mice. Am. J. Physiol. 278:F1030-F1033. (rapid publication)

Masseguin, C., M. Corcoran, C. Carcenac, N.G. Dauton, A. Guell, A.S. Verkman and J. Gabrion (2000). Altered gravity downregulates aquaporin-1 protein expression in choroid plexus. J. Appl. Physiol. 88:843-850.

Ma, T., Y. Song, B. Yang, A. Gillespie, E.J. Carlson, C.J. Epstein and A.S. Verkman (2000). Nephrogenic diabetes insipidus in mice deficient in aquaporin-3 water channels. Proc. Natl. Acad. Sci. U.S.A. 97:4386-4391.

Jayaraman, S. and A.S. Verkman (2000). Charge transfer mechanism for quenching of quinolinium fluorescence by halides. Biophys. Chem. 85:49-57.

Wang, K.S., T. Ma, F. Filiz, A.S. Verkman and J.A. Bastidas (2000). Colon water transport in transgenic mice lacking aquaporin-4 water channels. Am. J. Physiol. 279:G463-G470.

Song, Y., N. Fukuda, C. Bai, T. Ma, M.A. Matthay and A.S. Verkman (2000). Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in edema formation following lung injury. J. Physiol. 525:771-779.

Ma, T., S. Jayaraman, K.S. Wang, Y. Song, J. Li, J.A. Bastidas and A.S. Verkman (2001). Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am. J. Physiol. 280:C126-C134.

Lu, Y., I.R. Turnbull, A. Bragin, K. Carveth, A.S. Verkman and W.R. Skach (2000). Reorientation of aquaporin-1 topology during maturation in the endoplasmic reticulum. Mol. Biol. Cell 11:2973-2985.

Foster, W., A. Helm, I. Turnbull, H. Gulati, B. Yang, A.S. Verkman and W.R. Skach (2000). Identification of sequence determinants that direct different intracellular folding pathways for aquaporin-1 and aquaporin-4. J. Biol. Chem. 275:34157-34165.

Song, Y., B. Yang, M.A. Matthay, T. Ma and A.S. Verkman (2000). Role of aquaporin water channels in pleural fluid dynamics. Am. J. Physiol. 279:C1744-1750.

2000 Reviews

Verkman, A.S. and A.K. Mitra (2000). Structure and function of aquaporin water channels. Am. J. Physiol. 278:F13-F28.

Rao, S., and A.S. Verkman (2000). Analysis of functional organ physiology in transgenic mice. Am. J. Physiol. 279:C1-C18.

Verkman, A.S. (2000). Water permeability measurement in living cells and complex tissues. J. Membrane Biol. 173:73-87.

Verkman, A.S., B. Yang, Y. Song, G. Manley and T. Ma (2000). Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exper. Physiol. 85s:233S-241S.

Verkman, A.S., M.A. Matthay and Y. Song (2000). Aquaporin water channels and lung physiology. Am. J. Physiol. 278:L867-L879.

Verkman, A.S. (2000). Lessons from renal phenotype of aquaporin null mice. Curr. Opin. Nephrol. Hyperten. 9:517-522.